homefeedbacksupportlog on  11-Aug-2005 

Must Read
F1000 Factor 6.5

Postsynaptic receptor trafficking underlying a form of associative learning.
Rumpel S, LeDoux J, Zador A, Malinow R
Science 2005 Apr 1 308(5718):83-8 [abstract on PubMed] [related articles] [order article]
Selected by | Venkatesh Murthy / Eileen Lafer / Bradley Smith
First evaluation 14 Apr 2005 | Latest evaluation 18 Jul 2005
Relevant Sections

Faculty Comments
Faculty Member Comments
Venkatesh Murthy
Harvard University, United States of America

New Finding
This paper is exciting for two reasons: (i) it provides strong evidence that postsynaptic glutamate receptor trafficking is involved in synaptic plasticity, and (ii) it shows that perturbing normal synaptic plasticity in less than 20% of neurons in the lateral amygdala can interfere with fear conditioning. It is increasingly accepted that postsynaptic glutamate receptor traffic may underlie many forms of synaptic plasticity including long-term potentiation and long-term depression. While there is a glut of papers dissecting the molecular details of the regulation of glutamate receptor traffic, relatively few experiments have examined trafficking in the context of physiological processes. Using the well-studied amygdala-dependent behavioral paradigm of auditory fear conditioning, the authors show that new glutamate receptors are inserted into synapses of neurons in the lateral amygdala. Remarkably, when dominant negative fragments that block receptor insertion were introduced into as few as 20% of neurons in the lateral amygdala, fear conditioning was impaired.

Evaluated 18 Jul 2005
Eileen Lafer
University of Texas Health Sciences Center, United States of America

New Finding
This paper is important because it demonstrates that AMPA receptor trafficking is induced by associative learning. Moreover, the trafficking is pathway specific and necessary for learning. Disruption of receptor trafficking interferes with both amygdala LTP and fear conditioning, further strengthening the importance of receptor trafficking in memory formation.

Evaluated 15 Apr 2005
Bradley Smith
University of Notre Dame, United States of America

New Finding
In this paper, molecular-level changes in brain circuitry are investigated in the context of learning and conditioned response formation. Glutamate receptor trafficking is found to be a key event in the synaptic plasticity-based neuronal remodeling that leads to formation of memories, and it is also found that disrupting glutamate receptor trafficking can be detrimental to memory formation and associative learning.

Evaluated 14 Apr 2005
Faculty Comments

How to cite the Faculty of 1000 evaluation(s) for this paper

1) To cite all the evaluations for this article:

Faculty of 1000: evaluations for Rumpel S et al Science 2005 Apr 1 308 (5718) :83-8 http://www.f1000biology.com/article/15746389/evaluation

2) To cite an evaluation by a specific Faculty member:

Venkatesh Murthy: Faculty of 1000, 18 Jul 2005 http://www.f1000biology.com/article/15746389/evaluation

Eileen Lafer: Faculty of 1000, 15 Apr 2005 http://www.f1000biology.com/article/15746389/evaluation

Bradley Smith: Faculty of 1000, 14 Apr 2005 http://www.f1000biology.com/article/15746389/evaluation

Click here
Published by
1999-2005 Biology Reports Ltd unless otherwise stated < info@facultyof1000.com >  Terms and conditions